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In his seminal work, "Meditations on First Philosophy," René Descartes begins a philosophical journey to establish a firm foundation for knowledge. In the first two meditations, Descartes systematically dismantles his previous beliefs and sets the stage for his famous cogito ergo sum (I think, therefore I am) proposition.

Meditation One, "On the Things of Which We May Doubt," begins with Descartes' recognizing the fallibility of his senses and the susceptibility of his mind to deception. He notes that the senses have deceived him in the past, and he cannot be certain that what he perceives is real. This leads him to question the validity of all his beliefs, including those acquired through his senses and his reasoning.

Descartes then introduces the concept of the "evil genius." This is a powerful and deceptive being that could be systematically deceiving him about the nature of reality. This thought experiment becomes a powerful tool to undermine even his most firmly held beliefs. These include the existence of the external world and the reliability of his own cognitive faculties.

As Descartes explores deeper into this skeptical inquiry, he recognizes that even his most basic beliefs, including the existence of his own body, are not immune to doubt. This helps him realize that he cannot trust anything that he has previously believed to be true. Furthermore, he must start from a completely clean slate.

In Meditation Two, "On the Nature of the Human Mind," Descartes shifts his focus inward, exploring the nature of his own existence. He concludes that even if he doubts everything else, he cannot doubt the fact that he is thinking. This insight forms the foundation of his famous cogito ergo sum proposition, which establishes the existence of the thinking self as the one indubitable truth.

Descartes then considers the nature of this thinking self and concludes that it must be a non-material, immaterial substance – a "thing that thinks." He argues that the self cannot be identified with the body, as the body is subject to doubt and can be deceived. On the other hand, the thinking self remains constant and certain.

Furthermore, Descartes suggests that the mind, or the thinking self, is different from the physical world. It also operates according to its own internal logic and principles. This leads him to the idea of the mind as a separate substance, known as "mind-body dualism," which would become a central tenet of his philosophical system.

Throughout these meditations, Descartes employs a methodological strategy of radical doubt. He systematically questions and undermines all of his previous beliefs. This approach allows him to clear the ground for the construction of a new, more secure foundation for knowledge. The latter is grounded in the indubitable existence of the thinking self.

The significance of Descartes' meditations lies in their profound impact on the history of Western philosophy. He established the cogito as the bedrock of his philosophical system. This paved the way for a new understanding of the self, consciousness, and the relationship between the mind and the physical world. His work has continued to influence and shape debates in epistemology, metaphysics, and the philosophy of mind to this day.

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