Answer :
Final answer:
Graft rejection and graft-versus-host disease (GVHD) are rejection processes in organ transplants triggered by the recipient's immune response against donor tissue, involving immune cells targeting foreign cells.
Explanation:
Graft rejection occurs when the recipient's immune system views the transplanted organ or tissue as foreign, triggering an immune response. This rejection process involves the recognition of non-self molecules by the host's dendritic cells, activating cytotoxic T cells that target and kill the grafted cells.
Graft-versus-host disease (GVHD) is a type of rejection where donor T cells from the transplanted tissue attack the recipient's cells, leading to acute GVHD. This is a significant concern in bone marrow transplants due to the immune response mounted by the transplanted tissue.
Major histocompatibility complex markers (MHC I and MHC II), also known as human leukocyte antigens (HLAs), play a crucial role in transplant rejection by triggering the recipient's immune response against the donor tissue.
Learn more about organ transplant rejection here:
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